Optimization of the process of lyophilization of microbial culture of bacillus subtilis nbimcc 2353 by ultrasound
Lyophilization is a process in which water transforms from a solid to a gaseous aggregate state in a medium of vacuum and low temperature. In this type of processing of natural extracts, the biologically active substances in their composition remain unchanged. The continuous processing (24 - 72 hours), including freezing and drying in vacuum conditions and temperature regime from - 30℃ to + 30℃, is associated with a high energy consumption, which is a disadvantage of the method.