Aurora kinases expression and possible cancer risk indicator in individuals with diabetes melittus type 2
We aimed to verify the genomic instability in type 2 diabetes mellitus (DM2) by comparing the levels of AURKA and AURKB expression, commonly hyperexpressed in many tumors, in addition to the TP53 deletion status. Peripheral blood samples from 76 individuals, being 36 samples from individuals with DM2 and 40 samples from health donors were used. Significant differences were observed (AURKA: 2.013 ± 0.322 versus 1.126 ± 0.217, p < 0.0001, in DM2 versus health donors) and (AURKB: 1.600 ± 0.113 versus 1.133 ± 0.121, p < 0.0001, in DM2 versus health donors).