The genus Fusarium as source of the anti-leukemic enzyme l-asparaginase: adjustment of the productive conditions
The enzyme L-asparaginase is used to avoid acrylamide formation in food, and as a pharmaceutical to treat Acute Lymphoblastic Leukemia. As fungi are eukaryote and good enzyme producers, it is desirable to obtain a fungal L-asparaginase as an alternative to the bacterial enzymes that are currently used in the clinical practice. Glycerol use as carbon source for the metabolism of filamentous fungi is of great interest, once it can be used as a cheaper substrate for enzyme production, L-asparaginase alike, avoiding its discard in nature.