Severe immune thrombocytopenia in chronic lymphocytic leukemia (CLL)
Severe immune thrombocytopenia (ITP) is a frequently associated hematologic condition in CLL with low frequency in the earlier stages of the disease. The aim of the study was to correlate of severe ITP (platelet count <30x109/L) evidence in the earlier CLL stages with biological features, phenotypic and cytogenetic abnormalities and disease outcome. Twelve of 175 (6.9%) diagnosed CLL patients were with severe ITP. The ITP occurrence was significantly associated with ZAP-70 positivity (58%, p=0.028).