A study of the variation of serum uric acid in patients with and without diabetes mellitus who have normal renal function

1) Correlation of Serum Uric acid with Creatinine levels in male Diabetic population r=-0.048 and p>0.05 shows no significant correlation between serum uric acid and Creatinine levels. While in females r=0.270 and p<0.05 shows significant positive correlation between serum uric acid and Creatinine levels. 2) The correlation of Serum Uric acid with age in male Diabetic population r=- 0.0175 and p>0.05 shows no significant correlation between serum uric acid and age. In female Diabetic population r=-0.040 and p>0.05 also shows no significant correlation between serum uric acid and age. 3) With duration of Diabetes in male population r=0.388 and p<0.05 shows significant positive correlation between serum uric acid and duration of Diabetes. Whereas in female Diabetic population r=-0.159 and p>0.05 shows no significant correlation between serum uric acid and duration of Diabetes. 4) This study aimed to investigate the level of uric acid in Type 2 Diabetes mellitus patients and in non Diabetic controls with normal kidney function. This study also included the correlation of serum uric acid with glucose, creatinine, age, gender and duration of Diabetes. Uric acid levels were measured by Uricase- PAP methodology, FBS and PPBS levels by GOD- PAP methodology and creatinine by modified Jaffe’s kinetic method in 92 patients with Diabetes and 92 non Diabetic Controls and the uric acid levels were compared. The mean uric acid level showed no significant difference between Diabetic and non Diabetic population. The factors age, gender showed no significant correlation except in creatinine levels of female Diabetic population and duration of Diabetes in male diabetic population in which both showed a significant positive correlation with uric acid levels. 5) This study presents the pattern of relationship between serum uric acid, serum glucose and Diabetes mellitus of individuals with normal kidney function in a hospital based study. • No significant difference is seen between the mean levels of Uric acid in Diabetic and non Diabetic individuals. • No significant correlation is seen in the levels of uric acid with Glucose levels (FBS and PPBS), both in male and female Diabetic patients. • Serum Creatinine levels show no correlation with serum Uric acid levels in male Diabetic population while in female Diabetics, there is a significant positive correlation. • Pearson correlation shows no correlation with age and Uric acid levels in male and female Diabetic population. • The study also shows no significant difference in levels of uric acid with gender. • Duration of Diabetes in males show positive correlation with levels of uric acid, while no such correlation is observed in female diabetics. Since the cross sectional study show confounding data, the implication of uric acid levels in Diabetes and moreover in pre diabetes need to be investigated to a further extent.