Síndrome de ativação macrofágica e sua associação com atrite juvenil de origem idiopática

MAS is especially described as a secondary complication in children who have certain systemic diseases, and in most cases they are associated with systemic JIA. It is a pathology characterized by several non-specific signs and symptoms, which include: fever, cytopenias, hepatosplenomegaly with hepatic dysfunction and neurological alterations, among others. Due to the difficulty in the diagnosis and treatment of this pathology, it was verified the importance of analyzing through scientific publications the relationship between Macrophage Activation Syndrome and Idiopathic Juvenile Rheumatoid Arthritis. This is a qualitative literature review that is based on scientific production from scientific studies already published between the years 2007 to 2022. MAS is a worrying complication, which, among rheumatic diseases, most commonly affects patients with systemic juvenile idiopathic arthritis. It is characterized by fever, hepatosplenomegaly, cytopenias, liver dysfunction, hemorrhagic diathesis and neurological symptoms, expressing itself in a heterogeneous syndrome, which unfortunately makes its detection difficult. The presence of macrophages phagocytosing hematopoietic cells in the liver, spleen, bone marrow or lymph node can confirm the diagnosis. It is necessary to seek new ways of diagnosing these patients, since the complication has unspecific signs and symptoms common in other pathologies, the constant search for new treatments through clinical studies is essential in order to increase the quality and life expectancy of these patients.