Prognostic value of prolonged qtc interval and its dispersion in patients with stable coronary heart disease combined with nafld

Objectives: to evaluate the influence of prolonged corrected QT interval and its dispersion on the prognosis of the patients with stable coronary heart disease by a two-year cumulative proportion surviving depending on nonalcoholic fatty liver disease course. Methods: The study included 300 patients with stable coronary heart disease with and without nonalcoholic fatty liver disease. General clinical examination, electrocardiography, elastography, blood tests were conducted to all patients. Data obtained was compiled and statistical analysis was done. All parameters were reported as mean and standard deviation. Spearman correlation was used to calculate correlation between various variables. A P value <0.05 was considered statistically significant and P value >0.05 was considered non-significant. Kaplan-Meier survival of the patients was evaluated by two-year cumulative proportion surviving, the difference between groups was determined by Cox's F and Gehan's Wilcoxon tests. Conclusions: The severity of nonalcoholic fatty liver disease was associated with prolonged corrected QT interval and its dispersion that determined the most prognostically unfavorable course in patients with nonalcoholic steatohepatitis. Prolongation of corrected QT interval >440 msec and its dispersion >50 msec were associated with a high risk of cardio-vascular endpoints and caused significant reduction in the percentage of a two-year cumulative proportion surviving as the progression of nonalcoholic fatty liver disease in patients with stable coronary heart disease.