Phylogenetical relationships based in the 9 staged closed cycle of proton conductance and drug targets relating to some medicaments of traditional medicine
International Journal of Development Research
Phylogenetical relationships based in the 9 staged closed cycle of proton conductance and drug targets relating to some medicaments of traditional medicine
Received 12th October, 2018; Received in revised form 16th November, 2018; Accepted 24th December, 2018; Published online 30th January, 2019
Copyright © 2019, Ambaga and Tumen-Ulzii. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
According to theory of Traditional Medicine living rLung, Badgan, Mkhris are existed inside human body as gene, RNA, DNA, protons, electrons by ensuring all life processes as breath, blood circulation, food digestion, ageing, body growth. In this connection, according to theory of Traditional Medicine action of all medication methods of Traditional Medicine, including medicaments, acupuncture, moxibustion have been appeared in the level of living rLung, Badgan, Mkhris, which are existed inside human body together with genes, RNA, DNA, protons, electrons, “Donators + membrane - redox potentials three - state line system + O2 + АDP + Pi + H+ + nH+membrane space = (ATP + heat energy) + H2O + nH+matrix + CO2” reaction medium and CxHyOz - (X + Y/4 + Z/2) O2 + xCO2 +Y/2 H2O reaction medium. According to modern medicine the action of drugs on the human body is called pharmacodynamics, and what the body does with the drug is called pharmacokinetics. The drugs that enter the human tend to stimulate certain receptors, ion channels, act on enzymes or transporter proteins. One is form of universal common descent as “Donators + membrane-redox potentials three-state line system + O2 + АDP + Pi + H+ + nH+membrane space = (ATP + heat energy) + H2O + nH+matrix + CO2” reaction mediumhave been served the role of drug targets, relating to alldrugs not depending drugs either classified as Modern medicine drug, or as drug of Traditional medicine. Also, one is form of universal common descent as CxHyOz-(X+Y/4+Z/2) O2 + xCO2 + Y/2 H2O reaction medium have been served the role of drug targets, relating to all drugs not depending drugs either classified as Modern medicine drug, or as drug of Traditional medicine. We are considered that when drugs not depending drugs either classified as modern medicine drug, or as drug of Traditional medicine enter the human organism, reaching a drug targets as “Donators + membrane-redox potentials three - state line system + O2 + АDP + Pi + H+ + nH+membrane space = (ATP + heat energy) + H2O + nH+matrix + CO2” reaction medium would exert pharmacological effects. We are proposed that when drugs not depending drugs either classified as modern medicine drug, or as drug of Traditional medicine enter the human organism, reaching a drug targets as CxHyOz - (X + Y/4 + Z/2) O2 + xCO2 + Y/2 H2O reaction medium would exert pharmacological effects. We came to conclusion that when drugs not depending drugs either classified as modern medicine drug, or as drug of Traditional medicine enter the human organism, reaching a concrete drug targets as a molecular structure - chemically definable by a molecular mass, that will undergo a specific interaction with chemicals - drugs, tend to stimulate certain receptors, which are synthesized with participation of all genes by rule of genetic code identical for all all known life forms, descended from 16s rRNA gene, 18S rRNA, also descended from set of 355, comprising the three domains of life, archaea, bacteria, and eukaryotes, 6,331 genes common to all living animals have been identified. By us established that when drugs not depending drugs either classified as modern medicine drug, or as drug of Traditional medicine enter the human organism tend to stimulate certain proteins, descended from some 23 proteins, descended from a single common ancestor that lived 650 million years ago in the Precambrian, which are synthesized with participation of all genes by genetic code identical for all known life forms, descended from 16s rRNA gene, 18S rRNA, comprising the three domains of life, archaea, bacteria, and eukaryotes. It was clear that when drugs not depending drugs either classified as modern medicine drug, or as drug of Traditional medicine enter the human organism would cause the specific actions as affinity - measure of how tightly a drug binds to the receptors, which are synthesized with participation of all genes by general principle of genetic code identical for all all known life forms, comprising the three domains of life, archaea. We are denying the possibility of parallel existence of living rLung, Badgan, Mkhris (LBM), serving the role of Drug targets, relating to some medicaments of Traditional Medicinetogether with specific targets of drug actions as ion channels, receptors, all genes, descended from 16s rRNA gene, 18S rRNA, a set of 355 genes, comprising the three domains of life, archaea, bacteria, and eukaryotes, which are synthesized from pyrimidine and purine nucleotides, ATP molecules, generated within membrane - redox potentials three - state line system dependent - full 9 stepped cycle of proton conductance. It can be say that the continuity of proton conduction depended biosynthesis of ATP and NADPH using the membrane - redox potentials three - state line system like structures from the cyanobacteria to Homosapiens during last 4,5 billion years had been carried out by general principle as common descent of all life on Earth from the last universal common ancestor, comprising the three domains of life, archaea, bacteria, and eukaryotes, a genetic code identical for all known life forms, such postulation eventually gives the scientific ground to say that it is impossible of existing of the living rLung, Badgan, Mkhris, serving the role of Drug targets relating to some medicaments of Traditional Medicine. The universality of this code is generally regarded by biologists as definitive evidence in favor of universal common descent owing to membrane - redox potentials three - state line system like structures from the cyanobacteria to Homosapiens during last 4,5 billion years, such explanation eventually denied the possibility of existing of living rLung, Badgan, Mkhris, serving the role of Drug targets relating to some medicaments of Traditional Medicine. Theory of rLung, Badgan, Mkhris of Traditional Medicine (analogy and correspondence with theory of four humors) is abstract terms, reflecting the living things, existed inside human body as 16s rRNA gene, 18S rRNA, RNA, DNA, protons and electrons, the membrane - redox potentials three - state line system dependent - full 9 stepped cycle of proton conductance, a set of 355 genes, comprising the three domains of life, archaea, bacteria, and eukaryotes, and also genetic code, identical for all known life forms ( from bacteria and archaea to animals and plants), ensuring all life processes as breath, blood circulation, food digestion, ageing, body growth as specific targets of drug action, such interpretation have been witnessed the impossibility of existing of living rLung, Badgan, Mkhris as drug targets.