Evaluation of the implantation of the national neonatal screening program regarding coverage index, disease prevalence and sickle cell trait in mato grosso do sul - Brazil: 2001 – 2015

The National Neonatal Screening Program (PNTN) was implemented in Brazil in 2001. This program aims to improve coverage over 15 years and the prevalence of sickle cell disease and sickle cell trait. The objective of this manuscript was to evaluate in the last 15 years the work developed by the National Neonatal Screening Program regarding the coverage index, disease prevalence and sickle cell trait in the state of Mato Grosso do Sul, Brazil. It is a cross-sectional retrospective study carried out with the results of neonatal screening for hemoglobinopathies from 2001 to 2015. The high efficiency liquid chromatography technique was carried out at the Institute of Research, Teaching and Diagnosis of the Association of Parents and Friends of the exceptional in Mato Grosso do Sul. It was observed in the last 15 years that of the total of 612,909 live births, 543,690 were screened, reaching a Coverage index of 88.71%. Sickle cell anemia totaled 67 cases with a prevalence of 0.0127%, and 23 cases of FSC with a prevalence of 0.0046%. Heterozygotes (FAS) totaled 9,200 individuals with a prevalence of 1.6925. PNTN is a consolidated public policy in Mato Grosso do Sul, and its coverage index remained above 80% from 2001 to 2015. There was an increase in the number of cases of sickle cell disease HbSS and HbSC, as well as sickle cell trait.