Ion Selective Electrodes for Potentiometric Determination of Cyclizine in Its Pharmaceutical Dosage Form
International Journal of Development Research
Ion Selective Electrodes for Potentiometric Determination of Cyclizine in Its Pharmaceutical Dosage Form
Received 18th October, 2017; Received in revised form 07th November, 2017; Accepted 20th December, 2017; Published online 31st January, 2018.
Copyright ©2018 Seema Rani and Sarma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The two ion-pair complex of Cyclizine (Cy) with sodium tetraphenyl borate (TPB) and Phosphotungstic acid (PT) was prepared and used for the construction of Cy-selective electrode. The electrode based on the Cy-PT ion-pair complex has a lower detection limit of 1.5 x 10-7 M in a linear concentration range of 3.5 x 10-7 – 1.0 x 10-2 M with a slope of calibration curve of 50.5 mV/decay. The selectivity coefficient was calculated with separate solution method dictates the high selectivity of the electrode over other tested ions.
