Biochemical analysis of oxidative stress and purinergic system in hypertensive pregnant women

Introduction: Pregnancy is a physiological event, as well as a period of many expectations and questions, constituting a unique moment in the lives of many women. However, some women may present complications during pregnancy, among them, we can highlight Gestational Hypertension (GH) as causing several harmful effects to the maternal, fetal and neonatal organism. In this sense, recent studies indicate that there is a close relationship between hypertension and the purinergic system. Objective: To analyze the purinergic system and oxidative stress of hypertensive and non-hypertensive pregnant women in a Brazilian city. Methods: A quantitative survey was performed in which a total of 30 pregnant women, 15 of whom were at low risk (LR) and 15, with GH. Results: It was found that the hydrolysis of ATP and ADP indicated a greater activity of NTPDase in lymphocyte cells in pregnant women with GH. Conclusion: The analyzed components help in the vascular and endothelial regulation proper to the gestational period. Additionally, with regard to the parameters of the oxidative profile of the studied population, they showed a higher production of reactive oxygen species during the gestational period, which contributed to cell damage.