Nanocomposites films based on poly (lactic acid) for controled release of rifampicin
International Journal of Development Research
Nanocomposites films based on poly (lactic acid) for controled release of rifampicin
Received 22nd August, 2020; Received in revised form 19th September, 2020; Accepted 03rd October, 2020; Published online 30th November, 2020
Copyright © 2020, Luis Guilherme Magalhães dos Reis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Polymer nanocomposites have been successfully used as excipients in pharmaceutical technology, due to its various applications and features, especially in therapies for controlled drug release. The aim of this work was to prepare and characterize PLA nanocomposites by solution casting mode, with two different clays, sodic (NT25) and organoclay (Viscogel B8), focusing being possible used as matrices for controlled release of an important drug for tuberculosis, rifampicin. The systems were characterized by conventional technique such as XRD and by unconventional one, low-field NMR technique, relaxation, employing the determination of proton spin-lattice relaxation. The nanoscomposites obtained showed good dispersion and formation of nanomaterials containinga mixed morphology with different degrees of intercalation and exfoliation. Nanostructured poly(lactic acid) films were developed for modified Rifampicin release and based on the results, it can be concluded that both materials employing NT25 clay or Viscogel B8 clay exhibited a modified release of Rifampicin.
