MOLECULAR INVESTIGATION OF LEPTIN PROTEIN IN THE REVERSAL OF TYPE-II DIABETES MELLITUS

International Journal of Development Research

Volume: 
13
Article ID: 
27171
10 pages
Research Article

MOLECULAR INVESTIGATION OF LEPTIN PROTEIN IN THE REVERSAL OF TYPE-II DIABETES MELLITUS

Maha Amin, M Ali, Ahmad Naveed Bhatti and Samreen Riaz

Abstract: 

Insulin resistance and poor glucose control are two features of type 2 diabetes mellitus (T2DM), a chronic metabolic condition. Leptin, a hormone generated from adipose tissue, has become recognized as a possible therapeutic target in the treatment of type 2 diabetes. The current understanding of leptin's role in T2DM reversal is summed up in this abstract. Leptin has been discovered to have a variety of metabolic functions in addition to its traditional recognition for controlling hunger and energy balance. Leptin resistance frequently coexists with high levels of circulating leptin in people with obesity and type 2 diabetes, resulting in decreased responsiveness to its metabolic effects. Recent research, however, has shown that exogenous leptin injection can significantly enhance insulin sensitivity and glycemic control in some subgroups of T2DM patients.

DOI: 
https://doi.org/10.37118/ijdr.27171.11.2023
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