Isoeugenol efficacy against Staphylococcus aureus

International Journal of Development Research

Volume:

Article ID:

17034

3 pages

Research Article

Lyvia Layanne Silva Rosa, José Lucas Ferreira Marques Galvão, Hermes Diniz Neto, Jefferson Rodrigues Nóbrega, Daniele de Figuerêdo Silva, Francisco Patricio de Andrade Júnior, Pedro Thiago Ramalho de Figueiredo, Shellygton Lima Silva, Laísa Vilar Cordeiro, Abrahão Alves de Oliveira Filho and Edeltrudes de Oliveira Lima

Received 17th July, 2019; Received in revised form 21st August, 2019; Accepted 03rd September, 2019; Published online 30th October, 2019

Copyright © 2019, Lyvia Layanne Silva Rosa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract:

Background: Staphylococcus aureus is a Gram-positive bacterium responsible for the development of infections of varying degrees of complexity. In addition, due to resistance phenomena, treatment against this pathogen has become increasingly ineffective, making it necessary to search for new molecules with antibacterial activity. Objective: The present study aims to evaluate isoeugenol antibacterial activity against clinical strains of Staphylococcus aureus through in vitro assays. Methodology: It was held Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), Time-kill curve and checkerboard association of isoeugenol with standard antibiotic (gentamicin). Results: Isoeugenol presented 512 μg/mL MIC, > 4096 μg / mL in the MBC assay and demonstrated non-concentration-dependent bacteriostatic activity. The substance had synergistic and additive results when associated with gentamicin. Conclusion: Isoeugenol is an interesting alternative to be better understood, and further studies are needed to better investigate its mechanism of antibacterial action.

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