Investigation of molecular dynamics for the oxidation of chloramphenicol by cas in hoac-h2o 40% (v/v) medium

Chloramphenicol is a powerful antibiotic and is mostly used for curing both gram –negative and gram positive diseases. Ceric ammonium sulphate (CAS), a versatile oxidizing agent has been employed in acetic acid – water 40% (v/v) medium to oxidize the alcoholic groups present in chloramphenicol. This investigation has been carried out to evaluate the kinetic parameters such as rate with respect to each reactant and rate constant and thermodynamic parameters like Energy of activation(Ea), Enthalpy of activation(∆H#) and Entropy of activation(∆S#). With a help of these parameters the change in microbial activity of Chloramphenicol with respect to oxidation of alcoholic groups has been followed. A plausible mechanism has been suggested.