Inhibition of tumoral growth by hydroethanolic extract of peel from campomanesia adamantium (cambess) o. berg. in melanoma

Cerrado, Brazilian biome, presents numerous species of plants with pharmacological potential, among these, there is Campomanesia adamantium (Cambess.) O. Berg. (guavira) whose fruits are associated with various biological activities such as antiproliferative and antimutagenic action. Purpose of study was evaluate anticancer activity of hydroethanolic extract of guavira fruit peel and determine its acute oral toxicity.For this were used 25 male BALB/c mice inoculated with murine melanoma B16-F10 cells (5 x 105 / 0,2 µL), treated after 10 days in a single intraperitoneal dose, at doses of 2.5, 5, and 10 mg / animal, from guavira peel extract. For acute toxicity, female and male Swiss mice, 15 of each, were treated with concentrations of 50, 300 and 2000 mg / kg in single oral dose. Results showed anticancer action at 5 mg / animal concentration with up to 82% inhibition of tumoral growth. Acute oral toxicity test demonstrated a satisfactory result, since concentration of 2000 mg / kg did not lead any animal death, without significant changes related to hippocratic screening. Therefore, results found for guavira extract has great importance for confirmation of antitumor activity and stimulate deepening of studies to identify and isolate active compounds present in plant.