Genomic characteristics of human papilomavirus 16 and 18

There are more than 200 Human Papilloma Virus serotypes, or commonly called HPV (Human Papillomavirus), they participate in a frequent number of pathologies that can affect various organs of the human body. Among high-risk HPVs, serotypes 16 and 18 can be highlighted, since most of them are associated with potentially pre-neoplastic lesions in certain anogenital carcinomas, with high tropism for cervical cells. The present work aims to demonstrate the mechanism of action and replication of the obligate intracellular parasite HPV, correlating its protein potential in relation to the neoplasms caused by serotype 16 and 18. It was based on a systematic and bibliographic research on the human papillomavirus genome. serotype 16 and 18. In general, HPV 18 in its integration with the host cell involves disruption of the E1 and E2 gene along with retention of the Long Control Region (CRL) at its first contact within the cell nucleus. Such disruption is believed to have a relief in E7 gene expression because of E2 involvement in viral regulation. Regarding HPV 16 proteins, it can be seen that E6 is made up of 150 aminoacids and has two regions called the zinc finger (composed of two antiparallel beta-leaves and one alpha helix) that interact with zinc, significantly altering the apoptosis mechanism and cell proliferation. These HPVs are in greater contact with the genital regions and the lack of condom use and poor hygiene corroborate intraepithelial lesions causing various pathologies to the organism.