Formulation and Evaluation of Mucoadhesive tablet of Miconazole Nitrate by using Liquisolid Technique

Liquisolid technology is an effective technique for enhancing the solubility and dissolution properties of poorly water-soluble drugs. Miconazole, a broad-spectrum antifungal agent, is classified as a BCS Class II drug due to its limited water solubility and high lipophilicity, resulting in low oral bioavailability (approximately 25-30%) and an elimination half-life of 24 hours. This study aimed to improve the solubility and dissolution rate of miconazole using liquisolid technology and develop a mucoadhesive tablet formulation for buccal administration. The formulations were designed using Design Expert software (version 13, Stat-Ease), with PEG-400 as the solvent, MCC PH-102 and Aerosil 200 as the carrier and coating materials, respectively, and Carbopol 934 as the mucoadhesive agent along with Mannitol to enhance the drug release. Mucoadhesive liquisolid tablets were prepared using direct compression. FTIR studies confirmed no drug-excipient interactions. The prepared formulations were evaluated for precompression and post-compression parameters. The optimized formulation, F5, exhibited 87% drug release at 4 hours and a swelling index of 68%. This study demonstrated the effectiveness of liquisolid technology in improving the solubility and dissolution properties of poorly water-soluble drugs like Miconazole nitrate.