Formulation and development of famciclovir sustained release tablets using various retarding polymers
International Journal of Development Research
Formulation and development of famciclovir sustained release tablets using various retarding polymers
Received 18th January, 2023; Received in revised form 27th January, 2023; Accepted 11th February, 2023; Published online 28th February, 2023
Copyright©2023, A. Prem Chand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sustained release tablets of Famciclovir were formulated by using HPMC K15M and Ethyl cellulose. The tablets were evaluated for Preformulating studies like angle of repose, bulk density, compressibility index and physical characteristics like hardness, weight variation, friability and drug content. In-vitro release of drug was performed in 0.1 N HCL and phosphate buffer pH 6.8 for twelve hours. All the physical characters of the fabricated tablet were within acceptable limits. The tablet with Ethyl cellulose (F5) shows a better sustained drug release (99.23%) was obtained with the matrix tablet. It is cleared through the dissolution profile of Famciclovir from matrix tablets prepared using different polymers were indicated a low in the polymer ratio retarded the drug release to a greater extent.
