Formulation and Characterization of Phospholipid Complex of Matricaria Chamomilla Extract

The present study focuses on the formulation and characterization of a phospholipid complex of Matricaria chamomilla extract with the aim of improving its physicochemical properties and bioavailability. Although Matricaria chamomilla possesses significant pharmacological activities due to the presence of flavonoids, terpenoids, and other phenolic constituents, its therapeutic potential is often limited by poor solubility and low membrane permeability. To overcome these challenges, a phospholipid complex (phytosome) was prepared using phosphatidylcholine as a carrier to enhance lipid compatibility and systemic absorption. The formulated complex was characterized using various physicochemical parameters including percentage yield, entrapment efficiency, solubility studies, particle size analysis, zeta potential measurement, and Fourier Transform Infrared (FTIR) spectroscopy to confirm complex formation. The results indicated successful interaction between the extract and phospholipid, improved solubility, and enhanced stability compared to the plain extract. The phospholipid complex demonstrated favorable characteristics suggesting improved bioavailability and therapeutic potential.In conclusion, the development of a phospholipid complex of Matricaria chamomilla extract represents a promising strategy to enhance its delivery and pharmacological efficacy. This approach may contribute to the development of more effective herbal formulations with improved clinical performance.