Evaluation of a synergistic ayurvedic polyherbal formulation for the management of constipation: A pilot clinical study

Constipation is a prevalent and multifactorial gastrointestinal disorder affecting individuals globally, with higher incidence in females. This study evaluated a synergistic polyherbal-nutraceutical formulation containing Cassia angustifolia, Terminalia bellirica, Cassia fistula, Zingiberofficinale, Coleus forskohlii, Foeniculum vulgare, and rock salt, traditionally used to support digestive health. Preclinical quality assessments confirmed the formulation’s safety, potency, and compliance with pharmacopeial and regulatory standards. A 30-day open-label clinical trial involving 10 participants showed significant symptomatic improvement in 80% of cases with excellent tolerability and no adverse events. The pilot study suggests the potential benefits of this formulation in managing constipation.