Effects of clove oil on blood glucose level, lipid profile, lipid peroxidation, and kidney function on diabetic rats

Objective: The aim of this study was to investigate the hypoglycemic and hypolipidemic effect of clove oil and whether treatment with different doses of it could improve the kidney function in streptozotocin-induced diabetic rats.
Materials and Methods: Female albino rats (n=40) weighing (230-273 g) were divided into four groups. The first group (G1) served as control and consumed a standard diet. Diabetes was induced by injection of streptozotocin STZ (45 mg/kg body weight) to the other three groups. One diabetic group (G2) kept untreated and served as positive control. The other diabetic groups (G3 and G4) were treated with 300 mg/kg and 600 mg/kg of clove oil respectively.
Results: STZ-induced diabetic group exhibited very highly significant increase in serum glucose level and lipid profile (p<0.001) as compared to the control group. The serum levels of creatinine and urea as well as the tissue levels of malondialdehyde and nitric oxide were significantly increase too. A reduction in the levels of high density lipoprotein cholesterol level was registered. Diabetic groups treated with different doses of clove oil showed an improvement in the levels of glucose, insulin, lipid profile, urea, creatinine and lipid peroxidation when compared with untreated diabetic group. Histopathological changes of rat kidney coincided with biochemical changes.
Conclusion: This study demonstrated that clove oil produced significant reduction in glucose and lipid profile levels and shows remarkable ameliorates in kidney functions in diabetic rats. Therefor; the results of this study indicate that a dose of 600 mg/ kg of clove oil might be a beneficial adjuvant to oral hypolipidemic agents in diabetic patients.