Correlation of ferritin and d-dimer with tomographic lung injuries in covid-19

A retrospective study of 114 medical records from a cohort in the Amazon, northern Brazil, of individuals with COVID-19 during up to 14 days of infection, under outpatient control, was carried out through the analysis of inflammatory biomarkers (D-Dimer and Ferritin) and lung CT scans. This study was conducted in the same laboratory between January and April 2021. All participants were over 18 years old, of both sexes and residents in the state of Pará. Females were the majority (57%) and with ages between 46-60 years (40.4%). CT scans showed bilateral involvement (88.6%), around 10 to 25% of the lung fields (41.2%), containing lesions with thickening of the interlobular septa prevailing (29.8%). There was a predominance of the normality pattern of inflammatory biomarkers such as Ferritin (66.7%) and D-Dimer (74.6%). There was no relation between altered Ferritin and D-Dimer with a greater extent of involvement in lung CT images, ranging from 10-75%. The same clinical and laboratory behavior already recorded on several continents was observed, showing that the virus-host relationship is mediated by the immune response, and other parameters yet to be discovered that will define the clinical evolution of COVID-19, between mild, moderate and severe. Biomarker and tomographic parameters are of great importance in the joint analysis, supporting the decisions taken regarding keeping these patients out of hospital.