Comparison of experimental oral melanoma in mice and oral melanoma in dogs
International Journal of Development Research
Comparison of experimental oral melanoma in mice and oral melanoma in dogs
Received 27th July, 2019; Received in revised form 14th August, 2019; Accepted 19th September, 2019; Published online 30th October, 2019
Copyright © 2019, Louise Bach Kmetiuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Canine oral melanoma is a malignant tumor, with no reports onexperimentalmodel to date. Accordingly, the aim of this study was development the oral melanoma in mice and comparewith naturally occurring canine oral melanoma. A total of 30 C57BL/6J male mice received tumor induction, with euthanasia at 7th, 14th and 21thpost-operative days, and hemimandible resection. Macroscopic analyses have been performed in 18/30 (60.0%) mice. Morphological aspects and histopathologicalcharacteristics of the murine has shown similarities with canine oral melanoma. Thus, the murine oral melanoma may be useful, viable and reproducible alternative on preclinical study model for dogs.
