Comorbidities and mortality in elderly people with sars-cov: a systematic review and meta-analysis

The objective of this study is to review and synthesize findings of the presence of comorbidities and mortality in the elderly after SARS-CoV infection. A systematic review and meta-analysis were conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive systematic search was performed on Pubmed and EMBASE, to find articles published until May 2020. For the prevalence estimates of the included observational studies, a random effects meta-analysis model was used with the Variance Estimator. The data of 64643 patients presented in 15 articles were initially included in this study. According to the linear correlation analysis, in the elderly population investigated as explained comorbidities, approximately 70% (r² = 0.69) of mortality cases. Meta-analysis revealed that General mortality explained 62% of mortality in the elderly population studied (95% CI, 0.23-0.90; i2 = 100%) and a comorbidity in the elderly population with SARS-CoV 2 was 95% (95% CI, 0.58-1.00; i2 = 100%. In the present study, it is noticed that there is a moderate relation of deaths by SARS-Cov in patients with comorbidities and old age, the main hypothesis is the alteration of hemostasis and the compromised immune response, due to age.