Synthesis and antimicrobial activity of some new 3-amino-6-(2'-aminophenyl)-1,2,4-triazin-5(4h) one
International Journal of Development Research
Synthesis and antimicrobial activity of some new 3-amino-6-(2'-aminophenyl)-1,2,4-triazin-5(4h) one
Received 08th March, 2021; Received in revised form 17th April, 2021; Accepted 20th May, 2021; Published online 30th June, 2021
Copyright © 2021, Ola A. Abu Ali1 and Sherifa Mostafa M. Sabra. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
3-(Acyl/aroyl/ alkyl) amino-6- (2'-Acyl/aroyl/ alkyl) amino phenyl) - 1,2,4-triazin-5(4H) ones (3-10) have been synthesized derived from 3-amino-6-(2'-amino phenyl)- 1,2,4-triazin-5(4H) one (2). Structure of the new products have been established upon their elemental and spectral date. The newly prepared compounds showed good anti-microbial activity for more pathogenic microorganisms, prevalence of Staph. aureus growth and non-growth, that the growth had decreased almost at 9h and had increased number of non-growth bacteria by compound number 10. E. coli were inclined but less than Staph. aureus. Candida albicans growth had decreased almost at 9h. The most influential was the compound number (4, 8, 11 and 12). That concluded a promising template for anti-bacterial activities replacers.
