Susceptibility of multi-drug resistant staphylococcus aureus to combined extracts of uvaria chamae, holarrhena floribunda and senna occidentalis

×

Error message

User warning: The following theme is missing from the file system: journalijdr. For information about how to fix this, see the documentation page. in _drupal_trigger_error_with_delayed_logging() (line 1138 of /home2/journalijdr/public_html/includes/bootstrap.inc).

International Journal of Development Research

Volume: 
7
Article ID: 
9389
5 pages
Research Article

Susceptibility of multi-drug resistant staphylococcus aureus to combined extracts of uvaria chamae, holarrhena floribunda and senna occidentalis

Zumbes, H.J.,Babalola, O.B., Shittu, P.G., Dapiya H.S., Azi, H.Y., David, E.V., Pam, K.V., Dabo, D.A., Gokir, J.D. and Nvau, J.B.

Abstract: 

Multi-Drug Resistant Staphylococcus aureus (MRSA) is a serious clinical problem because of its ability to acquire resistance to most antibiotics which consequently reduce treatment successes. In the present study, efficacy of combined leaf extracts of U. chamae, H. floribunda and S. occidentalis against five multi-drug resistant Staphylococcus aureus isolated from wound swabs was evaluated. The antibiogram was determined by Kirby Bauer technique while in vitro antibacterial efficacy of the plant extracts evaluated using agar well diffusion. Preliminary phytochemical analysis of extracts revealed the presence of tannins, flavonoids, saponins, alkaloids, cardiac glycosides and terpenes. Combined leaf extracts of U. chamae, H. floribunda and S. occidentalis exhibited antibacterial activity against multi-drug resistant Staphylococcus aureus strains. The result showed that both aqueous and ethanolic extracts exhibited antibacterial activity against all Staphylococcus aureus strains. Inhibition was a direct function of concentration of extracts with almost 100% of organisms inhibited at all the concentrations used (400, 200, 100, 50, and 25mg/ml). The methanolic extracts were significantly more active than the aqueous extracts. Finding of this study suggest that the combined plant extracts can be alternative source of potent natural antibacterial agents for management of infections caused by multi-drug resistant Staphylococcus aureus.

Download PDF: