A study on the failure of transport protein

Life is maintained by cell metabolism. The most important factor in cell metabolism is protein production and destruction. Once created, the protein must function and be ubiquitin immediately. When a three-dimensional protein which formed the helix structure and a folded structure occurs a deformation, it interferes with cell metabolism and even causes cell necrosis. In particular, modification of structure in the transport protein degrades transporting ability of the substrate, and inhibits the passage of metabolites. It is a misfolding that is the main pattern for the modification of the steric structure of proteins. Abnormal folding is the most serious problem in protein structure. Misfolding of proteins is the main cause of DNA mutations. The misfolded protein fails to bind to the substrate to be transported. Changing the amino acids involved in the folding structure is a fundamental problem. Altering the amino acid residues associated with the side chain is the cause of misfolding. There is a need for a strategy to respond to misfolded proteins in drug development.