Screening of possible anti-inflammatory ligands of terminalia chebula against the stress related anaemia using docking studies

Sudhakar Malla, Sanjana, W.K. and Vaibhavi Chandrashekhar Dhuri

Anaemia a chronic disorder is a result of low levels of haemoglobin. The reduction in the levels of haemoglobin leads to several other complications in the body causing acute organ failure. Stress related anaemia is also at a pace in the modern world in view of the stressed life style. Interleukins were found to be more enhanced during stress related anaemia and as such the present study was focussed mainly to lower the levels of inflammatory molecules. Possible ligands were screened from Terminalia chebula and docked against the inflammatory molecules. The best candidate drug was selected basing on the best fit score in patchdock. Punicalagin, an active component of the plant was found to be more active in the study and further confirmation needs to be done both at invivo and invitro.

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   Vol. 07, Issue 02, February 2017



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