Rp-hplc method development and validation for the simultaneous determination of bromhexine and sulbactam in pharmaceutical dosage forms

  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/views.module on line 906.
  • strict warning: Declaration of views_handler_argument::init() should be compatible with views_handler::init(&$view, $options) in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/handlers/views_handler_argument.inc on line 744.
  • strict warning: Declaration of views_handler_filter::options_validate() should be compatible with views_handler::options_validate($form, &$form_state) in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/handlers/views_handler_filter.inc on line 607.
  • strict warning: Declaration of views_handler_filter::options_submit() should be compatible with views_handler::options_submit($form, &$form_state) in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/handlers/views_handler_filter.inc on line 607.
  • strict warning: Declaration of views_handler_filter_boolean_operator::value_validate() should be compatible with views_handler_filter::value_validate($form, &$form_state) in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/handlers/views_handler_filter_boolean_operator.inc on line 159.
  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/views.module on line 906.
  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/views.module on line 906.
Author: 
Venkata Raj Kumar Prava, Ganapati Seru, Siva Kumar Gubbala and Arun Sathyadev Siddhanadham
Abstract: 

Bromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, Bromhexine has antioxidant properties. Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract. The present study is to develop and validate a suitable RP-HPLC method for simultaneous estimation of Bromhexine and Sulbactam in pharmaceutical dosage forms in accordance with the ICH guidelines. Altima C18 (150 x 4.6 mm, 5mm) column was selected as the stationary phase. Phosphate buffer (pH 4), acetonitrile were taken in the ratio 40:60%v/v and used as mobile phase at a flow rate of 1.0 ml/min. The retention times of Bromhexine and Sulbactam were found to be 2.1 min & 3.2 min, respectively. The study clearly shows that the developed method can be successfully employed for routine quality control of Bromhexine and Sulbactam in drug testing laboratories and pharmaceutical industries

Download PDF: 

CHIEF EDITOR

  

           Prof. Dr. Bilal BİLGİN

Call for Papers - 2017

    submit your paper now

   Vol. 07, Issue 03, March 2017

CURRENT ISSUE

 

Article Tracking

IMPACT FACTOR 2016

          4.753

Get your Certificate

Copyright © 2016 International Journal Development Research. All Rights Reserved.