A review on pulmonary-renal syndromes

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Author: 
Basheer, S.K., Sulthan Shaheed, S.K., Jayasri, S., lakshmi Sai, K. and Satyanarayana, V.
Abstract: 

Pulmonary-renal syndromes are a group of disorders characterized by necrotizing glomerulo nephritis and pulmonary hemorrhage. The coexistence of circulating anti-neutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane (GBM) disease in children affected by this syndrome is exponential; with unfavorable out come in five out of seven patients reported to date. We describe a child with PRS associated both circulating anti-myeloperoxidase (anti-MPO) ANCA and anti-GBM disease on renal biopsy who was successfully treated with immunosuppressive therapy. The present article is to provide the intensivist with an overview of pulmonary-renal syndrome, focusing on new concepts of its pathogenesis and treatment innovations. Pulmonary-renal syndromes are a group of disorders characterized by necrotizing glomerulo nephritis and pulmonary hemorrhage. The coexistence of circulating anti-neutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane (GBM) disease in children affected by this syndrome is exponential; with unfavorable out come in five out of seven patients reported to date. We describe a child with PRS associated both circulating anti-myeloperoxidase (anti-MPO) ANCA and anti-GBM disease on renal biopsy who was successfully treated with immunosuppressive therapy. The present article is to provide the intensivist with an overview of pulmonary-renal syndrome, focusing on new concepts of its pathogenesis and treatment innovations.

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   Vol. 07, Issue 03, March 2017

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