Resveratrol effect on fructose-induced nash: A mechanistic approach

Enas A. Abd El-Haleim, Ashraf K. Bahgat and Samira Saleh

Background: High-fructose beverages have been extensively used in recent years leading to the development of NAFLD and NASH. The present study evaluates the effect of resveratrol on fructose-induced metabolic abnormalities in rats. A number of genes known to be critically involved in lipid metabolism were investigated.
Methods: Fructose-enriched diet (FED) was given to rats for 12 weeks. Resveratrol (RES) (70 mg/kg) was administered orally from the 9th week till the end of experimental period. Body weight, oral glucose tolerance test (OGTT), liver index, insulin resistance (HOMA), serum and liver triglycerides (TGs), oxidative stress (liver MDA, GSH and SOD), serum AST/ALT ratio and TNF-α were measured. Additionally, hepatic gene expression of suppressor of cytokine signaling -3 (SOCS-3), sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), malonyl CoA decarboxylase (MCD), transforming growth factor-β1 (TGF-β1) and adipose tissue gene expression of leptin and adiponectin was investigated.
Results: Resveratrol treatment ameliorated the fructose-induced damaged liver, glucose tolerance impairment, insulin resistance, oxidative stress & dyslipidemia. There was an improvement in genes responsible for NASH development.
Conclusions: Resveratrol improved the NASH-related fructose-induced disturbances due to its antioxidant and anti-inflammatory capacity beside its attenuating effects on hepatic genes expression and correcting the balance between adiponectin and leptin.

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