Relationships of sirt1 and 8-ohdg with resilience, depression and cognition in the elderly
International Journal of Development Research
Relationships of sirt1 and 8-ohdg with resilience, depression and cognition in the elderly
Received 27th April, 2017; Received in revised form 09th May, 2017; Accepted 16th June, 2017; Published online 31st July, 2017
Copyright ©2017, Dr. Raquel Maria Rossi Wosiack et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The aim of the present study was to evaluate the relationship of serum levels of SIRT1 and 8-OHdG with the psychological variables of resilience, depression and cognitive performance. The study design was quantitative and transversal. Data analyzed from 160 participants of both sexes, aged 60 to 79 years, using the following instruments: SIRT1, 8-OHdG, Resilience Scale, Geriatric Depression Scale and Mini Mental State Examination by the Mann Whitney tests for mean comparison, Spearman correlation and multiple linear regression using the stepwise method. The results demonstrated that there is a significant association between serum SIRT1 levels and resilience, depression and cognitive performance. However, in relation to 8-OHdG only one association with resilience was found. The conclusion was that coping with stressful events through the development of resilience, control of depression symptoms and maintenance of cognitive ability are associated with a good performance in the control of oxidative stress.
