Relationship between intrisic and extrinsic factors in klebsiellapneumoniae bacterium nosocomial infection patients with carbapenem resistance by new delhi metallo-β-lactamase 1 in medical and surgical cases

This article aimed to examine the relationship between intrinsic and extrinsic factors characteristics in the nosocomial infection case patients caused by the Klebsiella pneumoniaebacterium which is resistant to antibiotic of carbapenem type. The subjects of this study were the patients hospitalized at Dr. Hasan Sadikin General Hospital Bandung in the case of both medical and surgical experienced nosocomial infection in accordance with inclusion criteria reaching 287 cases. The study was conducted from the period of January 1 2015 to June 30 2015. The data were analized by using univariate test and bivariate with chi-square and comparison tests. The study revealed that the intrinsic factors relating to resistance of carbapenem were the Hb level on Cut off point ≤ 11.35 g/dL, the risk magnitude of resistance to Klebsiella pneumoniae bacterium was 2.38 times higher compared to Hb level> 11.35 g/dl; and major medical intervention reaches 3.03 times higher (CI 95%; 1.21–7.61); the factors relating to unhealing process in the nosocomial case were medical treatment case, leukocyte >16.600, minor medical intervention, and open skin condition, each of them had OR value of 2.89:2.09:5.05 and 1.88. There are significant differences between intrinsic (sex, age, nutritional status, and skin condition) and extrinsic factors (treatment duration, sample origin, and genera condition of the hospital) reaching p<0.05.