Pulmonary involvement in systemic lupus erythematosus

International Journal of Development Research

Pulmonary involvement in systemic lupus erythematosus

Abstract: 

Objective. The aim of this study was the identification of pulmonary manifestations in patients with systemic lupus erythematosus and their assessment in relation to immunological alterations. Methods. This is a cross-sectional study that analyzed 90 patients with systemic lupus erythematosus. Patients were examined by laboratory tests such as: anti-nuclear antibody, anti double stranded deoxyribonucleic acid antibody, anticardiolipin antibodies and D dimer. Pulmonary high-resolution computed tomography, computerized tomographic pulmonary angiography, pulmonary function tests and echocardiography doppler were performed for the patients. Results. Pleural effusion were 26 (28.9 %) patients. Interstitial lung disease were 9 (10 %) patients, acute lupus pneumonitis 2 (2.2 %) patients, pulmonary embolism 10 (11.1 %) patients and pulmonary arterial hypertension were 6 (6.7 %) patients. Restrictive ventilator insufficiency are 27 (30 %) patients. Conclusions. Pulmonary manifestations are common in systemic lupus erythematosus and have a wide spectrum. These injuries are anatomical and functional. Immunological alterations are important factors in pulmonary injuries.

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