Oxidative stress implications for the pathogenesis of ocular pathology

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International Journal of Development Research

Oxidative stress implications for the pathogenesis of ocular pathology

Abstract: 

The eyes are at particular risk for oxidative damage due to their high exposure to oxygen, a large amount of fatty acids in the retina and also high light exposure, environmental pollutants and ultraviolet rays. Oxidative stress to the largely retinal pigment epithelial cell layer (RPE) over time is reported to produce tissue dysfunction that contributes to the development of the pathogenesis of many diseases of the visual apparatus. The present paper discussed the evidence found about the possible role of oxidative damage in the pathogenesis of several eye diseases (glaucoma, cataract, diabetic retinopathy, macular degeneration) and the role of diet and antioxidant supplements in the prevention and treatment of such diseases. In recent years it has been suggested that free radicals and oxidative stress are part of this process, which fact is confirmed in many instances, it has been shown that the use of exogenous antioxidants preventive or stimulation of endogenous antioxidant systems retard appearance of the main signs and symptoms of ocular pathologies.

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