Orofacial manifestations of IGG-4-related disease in salivary glands: literature review
International Journal of Development Research
Orofacial manifestations of IGG-4-related disease in salivary glands: literature review
Received 10th December, 2020 Received in revised form 24th December, 2020 Accepted 18th January, 2021 Published online 24th February, 2021
Copyright © 2021, Letícia Côgo Marques et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: An updated review about the immunoglobulin G4-related disease to clarify and assist the dental surgeon in the diagnosis and treatment of this condition. Material and methods: The descriptors “IgG4-related disease” and “salivary glands” were searched in the virtual databases of PubMed, CAPES, Medline, BBO, LILACS and Scielo, from January 2018 to December 2020. The data included sex, age, systemic impairment, signs and symptoms and treatment. Results: 35 articles were selected, of which 12 were original articles, 17 case reports and six literature reviews. Conclusion: The salivary glands are the second organ most commonly involved in immunoglobulin G4-related disease; often the affected patients present a diffuse increase in volume of these glands, usually bilaterally, painlessly and persistently, with varying degrees of mouth dryness. Although the diagnosis is still a challenge, the dental surgeon must be aware of this condition, making a differential diagnosis with other diseases such as Sjögren’s syndrome and thus, helping in the correct diagnosis and treatment of comorbidities related to the disease.
