Severe acute respiratory syndrome: proposed new evidence-based treatment for sars-cov-2

The new coronavirus (SARS-CoV-2) pandemic is a worldwide challenge due to the urgent need to develop a treatment that reduces mortality from COVID-19 (new coronavirus disease). As there are still no drugs to combat SARS-CoV-2, the objective of this work was to search scientific information about SARS-CoV-2 and COVID-19 pathogenesis in order to propose a new evidence-based therapy. As a methodology, we use keywords released in the Medline index databases with crossing information. In the text we present the complex pathogenesis of COVID-19, with multiple factors that lead to severe lung injuries and the spread of the virus to other organs. Preliminary results from case studies and animal models of the disease suggest that there are two interconnected inflammatory pathways that must be inhibited simultaneously to interrupt the marked inflammatory process that occurs in severe cases: toll-like receptors and CCR5. With the analysis of the information obtained, we tried to find alternatives for possible interventions for simultaneous inhibition of the two main pro-inflammatory pathways probably involved in SARS-CoV-2.