Polymorphims in the cholesteryl ester transfer protein gene in patients with coronary artery disease
International Journal of Development Research
Polymorphims in the cholesteryl ester transfer protein gene in patients with coronary artery disease
Received 20th October, 2019; Received in revised form 08th November, 2019; Accepted 21st December, 2019; Published online 31st January, 2020
Copyright © 2020, Augusto Ferreira Correia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Introduction: Cholesterol ester transfer protein (CETP) is a plasma glycoprotein responsible for mediating the transfer of cholesterol esters and phospholipids, from high density LP (HDL) to low density LP, in exchange for TG. Materials and Methods: This is a cross-sectional, prospective and analytical study which enrolled 204 patients with coronary artery disease and 200 healthy controls. Evaluate the prevalence of polymorphisms in the CETP gene and its relationship with clinical characteristics. Results: Most patients analyzed in each group regarding the polymorphism of the CETP gene had the GG genotype (73.0% in the Disease group and 72.5% in the Control group), followed by those with the AG genotype (25.0% Control and 23.0% in the Disease group). The minority in each group had the AA genotype. Among patients with atherosclerosis, the prevalence of GG was higher in women and in obese patients. Conclusions: The AA genotype was less frequent in the patients and in the controls. This study did not identify any clinical characteristics more associated with AA genotype or A allele. However, in obese patients and in women GG genotype was more prevalent.
