THE BASIC KNOWLEDGES ABOUT THE POSSIBILTY OF EMPLOY THE MICRONUCLEUS TEST FOR THE DIAGNOSIS OF THE DOUBTH CASES IN THE SCREENING FOR THE DETERMINATION OF BREAST CANCER

Introduction and Objectives: The aim of this study is to check the possibility to use the  tests  with micronuclei in saliva for cases doubts detected in screening for breast cancer
Material and Methods: The principal search on Pub Med (MEDLINE), Home Genetic Reference is  for articles published  from Jan 1, 2000 to Dec 31, 2001,for the  keywords : "micronuclei in exfoliated buccal cells in breast cancer “ The key words are used in the research in free text, and  with  cross –referencing method application. Another search it is been made for   “MN in breast cancer “, from Jan1 2014 to today.
Results: Five studies show  that in buccal cells, in breast cancer  the MN are  significantly higher than compared to benign cases as in  six studies  for the detection of micronuclei in needle aspirates ductal,. Contrasting results are for MN in peripheral blood lymphocytes
Discussion: The  micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast cancer  while  the tests in peripheral blood lymphocytes , have known reproducibility  problems .The exfoliated buccal mucosa cells test, show an increase of MN. May be interesting to apply the MN scoring in cases of doubt, according to functional BI-RADS category 3 (probably benign), and which are sent to a control
Conclusions: it has verified that in buccal cells, in cases of breast cancer is significantly higher than the number of MN compared to benign cases, indicates the possibility of applying this technique in cases of doubt, in oral saliva.