Enhanced Outcomes in Recurrent Implantation Failure: A Case Study on the Application of Endometrial Receptivity Analysis (era)

This article addresses the impact of the endometrial receptivity array (ERA) methodology to increase implantation success rate after several implantation failure on embryo transfer. The cause of this failure may vary from the assumed inconsistency of the endometrial biopsy, the variable number of genes found to be dysregulated in endometrium samples without the embryonal-induced effect. This review aims to investigate if ERA was effective in optimizing the reproductive outcomes in a systematic way. As controlling for the embryo’s quality would allow for a more accurate assessment, we only analyzed the effects of ERA in euploid embryo transfer (EET) cycles. The intra-patient variations in the test need to be addressed. In summary, like all other add-ons, it is doubtful whether the ERA test use can significantly enhanceimplantation success rates. Summary: Couples could be counselled to undergo ERA during assisted reproductive technology treatment if a number of failed implantations in assumed inconsistency of the endometrial biopsy, the variable number of genes found to be dysregulated in endometrium samples without the embryonal-induced effect. At presentIn summary, like all other add-ons, it is doubtful whether the ERA test use can significantly enhance implantation success rates, but in this particular study, the result was satisfactory, although the outcome of further research is awaited.