Formulation and evaluation of oral disintegrating tablets of flurbiprofen
International Journal of Development Research
Formulation and evaluation of oral disintegrating tablets of flurbiprofen
Received 02nd January, 2023; Received in revised form 27th January, 2023; Accepted 20th February, 2023; Published online 28th February, 2023
Copyright©2023, Divya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The aim of this research is to formulate and evaluate Flurbiprofen Oral disintegrating Tablets. Flurbiprofen Indicated for the treatment of nonsteroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain. Hence in this investigation an attempt was made to develop oral disintegrating tablets of Flurbiprofen with super disintegrating agents likeKyron T-314, Poloxomer 188 and Ac-di-Sol. Oral disintegrate tablets were prepared by direct compression method. The tablets were evaluated for the precompression parameters such as bulk density, compressibility, angle of repose etc and post compression parameters like hardness, weight variation, friability, disintegration time, in-vitro dissolution studies.In vitro dissolution studies The formulation F6 consisting of Poloxomer 188was found be best among all the formulations it has exhibited faster disintegrating time (20 sec) when compared to other formulations and it showed 99.79 % drug release in 30min.
