The study of the pharmacokinetic predisposition and insilico metabolism of geraniol

Essential oil is one of the most used plant products in drug strategies and complementary treatments. Pharmacologically, they are known for their anti-bacterial, anti-viral, anti-fungal, anti-inflammatory potential, etc. The geraniol (GE) essential oil, found in plants such as: citronella, orange, "palmarosa" and geranium, has several therapeutic purposes through its regulation of multiple signaling pathways biological processes. Biological targets and bioavailability were analyzed using Swiss ADME software, based on the interaction of the molecule with cytochrome P450 enzymes. Metabolism was analyzed by simulating possible metabolic sites with SMART Cyp software and Swiss Target Prediction. A correlation was made between the data found and the existing literature in PubMed, Scielo and Google Scholar databases. From the data obtained, it was observed that GE, with lipid-soluble characteristics, according to the stages of absorption, distribution, metabolism and excretion, has the ability to interact with specific target sites and inhibit cytochrome P450 enzymes, as well as high absorption gastrointestinal tract and overcoming the natural barriers of protection. It is understood that in vitro and in vivo studies of efficacy (disease models) and safety (acute or chronic toxicity) are necessary to attest to the therapeutic properties of GE, emphasizing that in sílico studies when associated with these other types of studies, we have safe and very concrete results.