New validated rp-hplc method for the estimation of sumatriptan succinate in pharmaceutical formulation

×

Error message

User warning: The following theme is missing from the file system: journalijdr. For information about how to fix this, see the documentation page. in _drupal_trigger_error_with_delayed_logging() (line 1138 of /home2/journalijdr/public_html/includes/bootstrap.inc).

International Journal of Development Research

Volume: 
7
Article ID: 
9193
5 pages
Research Article

New validated rp-hplc method for the estimation of sumatriptan succinate in pharmaceutical formulation

Sivanadh, M.

Abstract: 

Introduction: A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Sumatriptan Succinate in Bulk and Pharmaceutical tablet Formulation. Isocratic elution at a flow rate of 1.5 ml/min was employed on symmetry Shimadzu LC-20 ATVP Kromasil C-18 column Column at ambient temperature. The mobile phase consisted of Orthophosphoric acid(1%):Acetonitrile : Methanol (90:5:5 v/v) . The UV detection wavelength was 210nm and 20 µl sample was injected. The run time for Sumatriptan Succinate is 6 min. The Percentage assay of Silymarin in formulation was found to be 100.08%. The amount of drug present in the human sample was found to be 0.287 mg/ ml The method was validated as per the ICH guidelines. The method was successfully applied for routine quality control analysis of pharmaceutical formulation. The HPLC method can be successfully applied for the routine quality control analysis of Sumatriptan Succinate formulations.

Download PDF: