Neonatal screening for Hemoglobin S

International Journal of Development Research

Article ID: 
5 pages
Research Article

Neonatal screening for Hemoglobin S

Nivea L. Torres, Maria L. Ivo, Olinda M. R. Araujo, Liane R. Giuliani, Alexandra M. A. Carvalho, Mylla Cristal Bôscolo Corrêa, Francine R. de Miranda, Berenice A. Kikuchi, Caroline Neris Ferreira Sarat and Valter Aragão do Nascimento


The aim of this manuscript was evaluate the Neonatal Screening Program for sickle cell disease from 2011 to 2015 in relation to its coverage and the prevalence of hemoglobin S. Methods: Cross-sectional observational study with results of Newborn Screening for sickle cell disease belonging to the database of the Research Institute, Study and Diagnostics of the Association of parents and friends of the exceptional. The variables studied were: number of children born alive; total screening; prevalence; time elapsed between the birth of the child and the collection of the screening; age at the time of the screening result. Prevalences were estimated by point and 95% confidence interval by Wald method adjusted using the Z distribution. Results: The numbers of live births was 213,739, but only 182,398 were screened for hemoglobinopathies, with a mean coverage index of 85.34%. In relation to the triage, 33 cases of sickle cell anemia were identified, 11 with FSC result and 3,328 had the result of sickle cell trait. Between the 3rd and 5th day of life were detected 25.5% of the collections. Conclusion: The average coverage index of the Neonatal Screening Program in the state of Mato Grosso do Sul / Brazil from 2011 to 2015 was 85.34%. Sickle cell anemia and FSC increased in number of cases. Sickle trait cases show gradual increase.

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