MOLECULAR INVESTIGATION OF LEPTIN PROTEIN IN THE REVERSAL OF TYPE-II DIABETES MELLITUS
International Journal of Development Research
MOLECULAR INVESTIGATION OF LEPTIN PROTEIN IN THE REVERSAL OF TYPE-II DIABETES MELLITUS
Received 17th August, 2023; Received in revised form 26th September, 2023; Accepted 10th October, 2023; Published online 27th Novemebr, 2023
Copyright©2023, Maha Amin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Insulin resistance and poor glucose control are two features of type 2 diabetes mellitus (T2DM), a chronic metabolic condition. Leptin, a hormone generated from adipose tissue, has become recognized as a possible therapeutic target in the treatment of type 2 diabetes. The current understanding of leptin's role in T2DM reversal is summed up in this abstract. Leptin has been discovered to have a variety of metabolic functions in addition to its traditional recognition for controlling hunger and energy balance. Leptin resistance frequently coexists with high levels of circulating leptin in people with obesity and type 2 diabetes, resulting in decreased responsiveness to its metabolic effects. Recent research, however, has shown that exogenous leptin injection can significantly enhance insulin sensitivity and glycemic control in some subgroups of T2DM patients.
