Molecular docking studies of MurA inhibitor with mdr gram negative pathogens

The problem of antimicrobial resistance was never taken to be such a threat to the management of infectious diseases. But gradually treatment failures were increasingly being seen in health care settings against first-line drugs and second line drugs or more. The bacterial cell wall is composed mainly of peptidoglycan and MurA catalyzes the first step in the biosynthesis of peptidoglycan. MurA transfers the enolpyruvyl group of phosphoenolpyruvate (PEP) to the 3'-hydroxyl group of UDP-Nacetylglucosamine (UNAG) to form UDP-Nacetylglucosamine (UDP-GlcNAc)- enolpyruvate. MurA is essential for cell growth, since deletion of the MurA gene in gram negative pathogens. There are three compounds docked with Vibrio cholerae, Haemophilus influenzae, Bacillus anthraces, E. coli. The compounds have good docking score and glide energy. These compounds will acts as leads compounds for gram negative MDR pathogens.