Microwave synthesis, spectral characterization DNA - binding studies and biological activity of Cr(III), Co(II), Ni(II), Hg(II) and Cd(II) complexes with nicotinic acid hydrazide and nitrite mixed ligand complexes

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International Journal of Development Research

Microwave synthesis, spectral characterization DNA - binding studies and biological activity of Cr(III), Co(II), Ni(II), Hg(II) and Cd(II) complexes with nicotinic acid hydrazide and nitrite mixed ligand complexes

Abstract: 

The complexes of Cr(III), Co(II), Ni(II), Hg(II), Cd(II) were microwave synthesized with the ligands Nicotinicacidhydrazide and (ONO)2 and characterized by using Elemental analysis, Molar conductance measurements, IR, NMR, spectroscopic studies. DNA-binding properties have been studied by electronic absorption, emission, viscosity and cyclic voltametric methods. The results suggest that the copper (II) complex bind to DNA via different modes. Gel electrophoresis study reveals the fact that the copper complex cleaves super coiled pBR 322 DNA to nicked and linear forms in the presence and absence of nicotinicacidhydrazide. The in vitro antimicrobial study indicates that the complex has good activity against gram positive, gram negative bacteria and fungus. The fungal activity data shows that the metal complexes are potent active then the parent ligand NHA.

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