Histological effects of fluoride on cerebrum of adult albino rats

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International Journal of Development Research

Histological effects of fluoride on cerebrum of adult albino rats

Abstract: 

The pilot study was conducted on 10 adult albino rats of either sex 150-200gm each. Two equal groups of control and experimental was made. The control group received food and water ad libitum whereas experimental group received 30 ppm of NaF for 8 weeks. The macroscopic features like body weight, general activity was markedly reduced in experimental group pertaining to high fluoride levels in the brain. Light microscopy of cerebrum in experimental group revealed decreased density of neurons, high mitotic figures. The density of neurons was reduced to 93.4 cells / cumm from 149.6 cells / cumm in control.

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