Formulation and Evaluation of Ph Sensitive In Situ Ocular Gel of Doxycycline Hyclate

Several new preparations have been developed for ophthalmic use, not only to prolong the Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. The challenge to the formulator is to circumvent the protective barriers of the eye without causing permanent tissue damage. The primitive ophthalmic solutions, suspensions and ointment dosage forms are clearly no longer sufficient to combat some present virulent diseases. Due to tear drainage, most of the administered dose passes via the naso-lacrimal duct into the gastro intestinal tract (GIT), leading to side effects. Rapid elimination of the eye drops administered often results in a short duration of the therapeutic effect making a frequent dosing regimen necessary. To overcome such drawbacks of conventional ophthalmic drug delivery the present work is focused on Formulation and evaluation of Ph sensitive in situ ocular gel of deoxycycline hyclate.